Prurigo nodularis
☆ ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
References
Prurigo nodularis ເປັນສະພາບຜິວໜັງທີ່ຕິດມາດົນນານ ເຊິ່ງມີລັກສະນະເປັນຕຸ່ມໆ ແລະ ຕ່ອມ, ມັກຈະພົບຢູ່ບໍລິເວນນອກຂອງແຂນ ແລະ ຂາ. ຜິວໜັງເຫຼົ່ານີ້ສາມາດປ່ຽນສີຈາກເນື້ອໜັງໄປເປັນສີບົວ ແລະມີອາການຄັນຫຼາຍ. ພວກເຂົາສາມາດສົ່ງຜົນກະທົບຕໍ່ຄົນໃນທຸກໄວແລະມັກຈະພົວພັນກັບສະພາບຜິວຫນັງອື່ນໆທີ່ເຮັດໃຫ້ເກີດອາການຄັນຊໍາເຮື້ອ, ເຊັ່ນ: ຜິວຫນັງ atopic. ທາງເລືອກໃນການປິ່ນປົວລວມມີຢາຕ້ານອາການຄັນທີ່ເຂັ້ມແຂງ, ຢາທີ່ມີຜົນກະທົບຕໍ່ລະບົບພູມຕ້ານທານ, ແລະຢາທີ່ແນໃສ່ລະບົບປະສາດ. ການຄຸ້ມຄອງ prurigo nodularis ປົກກະຕິແລ້ວກ່ຽວຂ້ອງກັບການປິ່ນປົວໄລຍະຍາວ.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
ການປິ່ນປົວມັກຈະກ່ຽວຂ້ອງກັບການໃຊ້ສີຄີມຫຼືສີດຢາສະເຕີຣອຍໃສ່ພື້ນທີ່ທີ່ຖືກກະທົບ. ໃນກໍລະນີທີ່ຮຸນແຮງ ຫຼືແຂງກະດ້າງກວ່າ, ການປິ່ນປົວເຊັ່ນ: ການປິ່ນປົວດ້ວຍແສງ ຫຼືຢາທີ່ສະກັດກັ້ນລະບົບພູມຄຸ້ມກັນອາດຈະຈໍາເປັນ. Thalidomide ແລະ lenalidomide ແມ່ນທາງເລືອກສໍາລັບກໍລະນີຮ້າຍແຮງ, ແຕ່ພວກມັນສາມາດມີຜົນຂ້າງຄຽງທີ່ຮ້າຍແຮງ. ການປິ່ນປົວໃຫມ່ (opioid receptor antagonists, neurokinin-1 receptor antagonists) ສະແດງໃຫ້ເຫັນຄໍາສັນຍາໃນການປິ່ນປົວ prurigo nodularis ທີ່ມີຜົນຂ້າງຄຽງຫນ້ອຍກວ່າເມື່ອທຽບກັບ thalidomide ຫຼື lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo ເປັນສະພາບຜິວໜັງທີ່ມີອາການຄັນເປັນປະຈຳ (ຢູ່ໄດ້ດົນກວ່າ 6 ອາທິດ) , ຮອຍຂີດຂ່ວນຕາມຜິວໜັງ ແລະ ມີປະຫວັດການຂູດເປັນປະຈຳ. ມັນກ່ຽວຂ້ອງກັບການອັກເສບ neuroinflammation ແລະ fibrosis ໃນຜິວຫນັງ.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis ເປັນບັນຫາຜິວທີ່ຕິດທົນນານ ມີອາການຄັນ. ພວກເຮົາບໍ່ຮູ້ວ່າສາເຫດຂອງມັນແມ່ນຫຍັງ, ແຕ່ມັນເບິ່ງຄືວ່າບັນຫາພູມຕ້ານທານແລະເສັ້ນປະສາດມີບົດບາດໃນວົງຈອນການເກີດອາການຄັນ. ໃນປັດຈຸບັນ, ບໍ່ມີການປິ່ນປົວໃດໆທີ່ໄດ້ຮັບການອະນຸມັດໂດຍ FDA ສະຫະລັດໂດຍສະເພາະສໍາລັບ prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
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